Martin Brundle, born of the human/fly, is adopted by his father's place of employment (Bartok Inc.) while the employees simply wait for his mutant chromosomes to come out of their dormant state.
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| Directing | Chris Walas | Director |
| Production | Steven-Charles Jaffe | Producer |
| Writing | Jim Wheat | Screenplay |
| Writing | Ken Wheat | Screenplay |
| Writing | Frank Darabont | Screenplay |
| Camera | Robin Vidgeon | Director of Photography |
| Editing | Sean Barton | Editor |
| Writing | Mick Garris | Screenplay |
| Visual Effects | Chris Walas | Effects Supervisor |
| Production | Deborah Lucchesi | Casting |
| Costume & Make-Up | Christopher Ryan | Costume Design |
| Editing | John Watson | Assistant Editor |
| Art | Michael S. Bolton | Production Design |
| Art | Sandy Cochrane | Art Direction |
| Art | Rose Marie McSherry | Set Decoration |
| Costume & Make-Up | Sherry Linder-Gygli | Hairstylist |
| Costume & Make-Up | Jayne Dancose | Makeup Artist |
| Art | Thom Wells | Construction Coordinator |
| Art | Glen W. Pearson | Assistant Art Director |
| Art | Steve Craine | Lead Painter |
| Art | Avo Liva | Greensman |
| Crew | James H. Chow | Property Master |
| Sound | Patrick Dodd | ADR & Dubbing |
| Sound | Leslie Shatz | Sound Designer |
| Sound | Ralph Wikke | Sound Effects Editor |
| Editing | Patrick Dodd | Dialogue Editor |
| Sound | Danny Kopelson | Sound Re-Recording Mixer |
| Sound | David Parker | Sound Re-Recording Mixer |
| Visual Effects | Katherine Kean | Animation |
| Visual Effects | January Nordman | Animation |
| Visual Effects | Joseph Thomas | Animation |
| Visual Effects | John T. Van Vliet | Animation |
| Crew | John Wardlow | Stunt Coordinator |
| Camera | John Clothier | Steadicam Operator |
| Camera | Joseph Lederer | Still Photographer |
| Lighting | Stephen Jackson | Gaffer |
| Lighting | Richard Buckmaster | Rigging Gaffer |
| Production | Michelle Allen | Casting |
| Editing | Jay Ignaszewski | First Assistant Editor |
| Editing | Michael Smith | First Assistant Editor |
| Sound | Earl Ghaffari | Music Editor |
| Sound | Jay Ignaszewski | Music Editor |
| Directing | Jean Bereziuk | Script Supervisor |
| Production | Tracey Jeffrey | Location Manager |
| Crew | Steve Newman | Unit Publicist |
| Camera | Cyrus Block | Camera Operator |
| Writing | George Langelaan | Characters |
| Writing | Mick Garris | Story |
| Costume & Make-Up | Stephan Dupuis | Special Effects Makeup Artist |
| Costume & Make-Up | Dennis Pawlik | Special Effects Makeup Artist |
| Costume & Make-Up | Jo-Anne Smith-Ojeil | Special Effects Makeup Artist |
| Costume & Make-Up | Sydney Silvert | Assistant Makeup Artist |
| Costume & Make-Up | Brenda Turner | Assistant Hairstylist |
| Production | Gillian Richardson | Associate Producer |
| Directing | Richard Coleman | Second Assistant Director |
| Directing | Peter D. Marshall | First Assistant Director |
| Directing | Kenna Marshall-Pittman | Third Assistant Director |
| Directing | Peter Talbot | Assistant Director Trainee |
| Production | Mel Brooks | Producer |
| Production | Stuart Cornfeld | Executive Producer |
| Sound | Christopher Young | Original Music Composer |
