When a professor develops a vaccine that eliminates human allergies to dogs, he unwittingly upsets the fragile balance of power between cats and dogs and touches off an epic battle for pet supremacy. The fur flies as the feline faction, led by Mr. Tinkles, squares off against wide-eyed puppy Lou and his canine cohorts.
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| Directing | Lawrence Guterman | Director |
| Writing | Glenn Ficarra | Screenplay |
| Writing | John Requa | Screenplay |
| Production | Christopher DeFaria | Producer |
| Sound | John Debney | Original Music Composer |
| Camera | Julio Macat | Director of Photography |
| Editing | Rick Finney | Editor |
| Visual Effects | Eric Oliver | Animation |
| Writing | Bob Camp | Storyboard |
| Sound | Mark Mangini | Supervising Dialogue Editor |
| Crew | J.J. Makaro | Stunt Coordinator |
| Visual Effects | Bill Westenhofer | Visual Effects Supervisor |
| Production | Chris Bender | Executive Producer |
| Production | Warren Zide | Producer |
| Production | Andrew Lazar | Producer |
| Production | Craig Perry | Producer |
| Production | Bruce Berman | Executive Producer |
| Costume & Make-Up | Tish Monaghan | Costume Design |
| Art | James D. Bissell | Production Design |
| Production | J.C. Spink | Executive Producer |
| Editing | Michael A. Stevenson | Editor |
| Editing | Jason Tucker | First Assistant Editor |
| Visual Effects | John Slattery | Digital Compositor |
| Visual Effects | Craig Barron | Visual Effects Supervisor |
