The Newton family live in their comfortable home, but there seems to something missing. This "hole" is filled by a small puppy, who walks into their home and their lives. Beethoven, as he is named, grows into a giant of a dog... a St Bernard. Doctor Varnick, the local vet has a secret and horrible sideline, which requires lots of dogs for experiments. Beethoven is on the bad doctor's list.
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| Production | Joe Medjuck | Producer |
| Camera | Victor J. Kemper | Director of Photography |
| Editing | William D. Gordean | Editor |
| Editing | Sheldon Kahn | Editor |
| Production | Michael C. Gross | Producer |
| Production | Ivan Reitman | Executive Producer |
| Directing | Brian Levant | Director |
| Camera | Bruce McBroom | Still Photographer |
| Crew | Chad Randall | Stunts |
| Sound | Charles M. Wilborn | Production Sound Mixer |
| Art | Greg Lynch | Leadman |
| Camera | Bill Roe | Camera Operator |
| Art | Rick Young | Property Master |
| Art | Stan Tropp | Set Designer |
| Art | Eric A. Hulett | Set Dresser |
| Lighting | Rhio Haessig | Best Boy Electric |
| Camera | Gaylin P. Schultz | Key Grip |
| Camera | Audie Aragon | Best Boy Grip |
| Sound | Kenneth Schwarz | Boom Operator |
| Crew | Thomas Robinson Harper | Stunts |
| Production | Ira S. Rosenstein | Location Manager |
| Crew | Gloria Hoffman | Studio Teacher |
| Art | Gary Diamond | Set Designer |
| Art | Kurt V. Hulett | Set Dresser |
| Crew | Gregory J. Barnett | Stunts |
| Crew | Ralph W. Odum | Stunts |
| Costume & Make-Up | Margo Baxley | Costume Supervisor |
| Lighting | Frank Dorowsky | Electrician |
| Production | Peter J. Novak | Assistant Location Manager |
| Production | Alan Berger | Casting Associate |
| Crew | Craig Pinkard | Transportation Coordinator |
| Crew | Cliff Wenger | Special Effects |
| Production | Ellen Adolph | Production Accountant |
| Camera | Brad Rea | Dolly Grip |
| Crew | Marcy Bolotin | Unit Publicist |
| Crew | John J. Downey | Special Effects |
| Art | George Stokes | Construction Coordinator |
| Sound | Roxanne Jones McCarthy | Supervising Sound Editor |
| Sound | John O. Wilde | Sound Effects Editor |
| Sound | Mark R. La Pointe | Sound Effects Editor |
| Directing | Michael C. Gross | Second Unit Director |
| Sound | William Hartman | Sound Effects Editor |
| Sound | Harry Cheney | Sound Effects Editor |
| Sound | Victor B. Lackey | Sound Effects Editor |
| Sound | Greig McRitchie | Orchestrator |
| Camera | John M. Stephens | Second Unit Director of Photography |
| Editing | Gregory Gontz | Assistant Editor |
| Sound | David B. Cohn | Supervising ADR Editor |
| Directing | Ira S. Rosenstein | Second Unit First Assistant Director |
| Sound | Tom McCarthy Jr. | Supervising Sound Editor |
| Directing | Glenn Randall Jr. | Second Unit Director |
| Directing | Tracy Rosenthal-Newsom | Second Unit First Assistant Director |
| Editing | Reid Burns | Color Timer |
| Sound | Don S. Walden | Sound Effects Editor |
| Editing | John Currin | Assistant Editor |
| Sound | David Williams | Sound Effects Editor |
| Sound | Adam Jenkins | Sound Re-Recording Mixer |
| Sound | Gary C. Bourgeois | Sound Re-Recording Mixer |
| Costume & Make-Up | Leslie Weir | Costumer |
| Costume & Make-Up | Adrienne Manhan | Costumer |
| Sound | Scott Millan | Sound Re-Recording Mixer |
| Sound | David W. Alstadter | Foley Recordist |
| Lighting | Earl Gilbert | Chief Lighting Technician |
| Art | James F. Orendorff | Construction Foreman |
| Crew | Buddy Joe Hooker | Stunt Coordinator |
| Crew | Janet Brady | Stunts |
| Crew | Bobby Bass | Stunts |
| Crew | John C. Meier | Stunts |
| Crew | Billy Hank Hooker | Stunts |
| Crew | Buddy Joe Hooker | Stunts |
| Crew | Danny Epper | Stunts |
| Art | Alex Tavoularis | Production Design |
| Art | Charles William Breen | Art Direction |
| Writing | Amy Holden Jones | Writer |
| Sound | Randy Edelman | Original Music Composer |
| Production | Steven Jacobs | Casting Director |
| Costume & Make-Up | Gloria Gresham | Costume Design |
| Production | Gordon A. Webb | Co-Producer |
| Production | Gordon A. Webb | Unit Production Manager |
| Directing | Jerram A. Swartz | First Assistant Director |
| Directing | Todd Corman | Second Assistant Director |
| Writing | John Hughes | Writer |
| Costume & Make-Up | James R. Scribner | Makeup Artist |
| Costume & Make-Up | Allen Payne | Hairstylist |
| Art | Gary Fettis | Set Decoration |
| Costume & Make-Up | Ken Chase | Makeup Artist |
| Costume & Make-Up | Susan V. Kalinowski | Hairstylist |
