Holmes and Watson board a passenger train bound from London to Edinburgh, to guard the Star of Rhodesia, an enormous diamond worth a fortune belonging to an elderly woman of wealth; but within the first hour of the trip, the woman's son is murdered and the diamond stolen and any of the passengers in their car could be the killer thief.
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| Directing | Roy William Neill | Director |
| Writing | Frank Gruber | Screenplay |
| Camera | Maury Gertsman | Director of Photography |
| Editing | Saul A. Goodkind | Editor |
| Sound | Milton Rosen | Music Director |
| Art | John B. Goodman | Art Direction |
| Art | Abraham Grossman | Art Direction |
| Sound | Bernard B. Brown | Sound Director |
| Art | Russell A. Gausman | Set Decoration |
| Art | Carl Lawrence | Set Decoration |
| Costume & Make-Up | Vera West | Costume Design |
| Costume & Make-Up | Carmen Dirigo | Hairstylist |
| Costume & Make-Up | Jack Pierce | Makeup Department Head |
| Production | Howard Benedict | Executive Producer |
| Production | Roy William Neill | Producer |
| Writing | Arthur Conan Doyle | Novel |
| Sound | Jack A. Bolger, Jr. | Sound Engineer |
| Crew | Raymond Kessler | Dialogue Coach |
| Directing | Melville Shyer | Assistant Director |
