The film chronicles George's adventures as he befriends Kayla, a baby elephant, at a magic circus show and helps her travel across the country to be reunited with her family.Accompanied by his friend, the Man with the Yellow Hat, George travels by foot, train, and truck to reach Kayla's brother and sister in California, only to be accused of elephant-napping and brought all the way back to New York.
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| Directing | Norton Virgien | Director |
| Art | Matt Williames | Art Department Manager |
| Production | David Bernardi | Co-Executive Producer |
| Production | Brian Grazer | Executive Producer |
| Writing | Andrei Svislotski | Head of Story |
| Sound | Slamm Andrews | Music Editor |
| Writing | Chuck Tately | Story |
| Editing | John Bryant | Editor |
| Sound | Heitor Pereira | Original Music Composer |
| Production | Ron Howard | Executive Producer |
| Writing | Darrell Rooney | Story |
| Production | Susan Blu | Casting |
| Production | Jim Whitaker | Co-Executive Producer |
| Sound | Elliott Koretz | Sound Effects Editor |
| Production | Share Stallings | Producer |
| Sound | Frederick Howard | Sound Supervisor |
| Production | Jon Shapiro | Executive Producer |
| Production | Leanne Moreau | Associate Producer |
| Production | David Vasquez | Production Coordinator |
| Sound | Jeff Rosen | Dialogue Editor |
| Art | Bob Kline | Art Direction |
| Writing | Chuck Tately | Screenplay |
| Sound | Derek Pippert | Foley Supervisor |
| Production | David Kirschner | Executive Producer |
