Research chemist Barnaby Fulton works on a fountain of youth pill for a chemical company. One of the labs chimps gets loose in the laboratory and mixes chemicals, but then pours the mix into the water cooler. When trying one of his own samples, washed down with water from the cooler, Fulton begins to act just like a twenty-year-old and believes his potion is working. Soon his wife and boss are also behaving like children.
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| Editing | William B. Murphy | Editor |
| Writing | Ben Hecht | Screenplay |
| Directing | Howard Hawks | Director |
| Writing | Charles Lederer | Screenplay |
| Production | Sol C. Siegel | Producer |
| Directing | Don Torpin | Assistant Director |
| Costume & Make-Up | Louise Miehle | Hairstylist |
| Directing | Paul Helmick | Assistant Director |
| Costume & Make-Up | Helen Turpin | Hairstylist |
| Costume & Make-Up | Esperanza Corona | Hairstylist |
| Costume & Make-Up | Allan Snyder | Makeup Artist |
| Writing | Howard Hawks | Screenplay |
| Costume & Make-Up | Bill Riddle | Makeup Artist |
| Camera | Milton Krasner | Director of Photography |
| Writing | I. A. L. Diamond | Screenplay |
| Art | Thomas Little | Set Decoration |
| Writing | Harry Segall | Story |
| Art | George Patrick | Art Direction |
| Art | Walter M. Scott | Set Decoration |
| Art | Lyle R. Wheeler | Art Direction |
| Costume & Make-Up | Travilla | Costume Designer |
| Sound | Lionel Newman | Music Director |
| Costume & Make-Up | Ben Nye | Makeup Artist |
| Costume & Make-Up | Charles LeMaire | Other |
| Sound | Leigh Harline | Music |
| Sound | Roger Heman Sr. | Sound |
| Sound | W. D. Flick | Sound |
| Crew | Ray Kellogg | Special Effects |
| Sound | Earle Hagen | Orchestrator |
