Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider. Based on "The Sign of Four" and the short stories "The Dying Detective", "The Final Problem", "The Speckled Band" and "The Adventure of the Devil's Foot".
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| Directing | Roy William Neill | Director |
| Writing | Bertram Millhauser | Screenplay |
| Production | Roy William Neill | Producer |
| Camera | Charles Van Enger | Director of Photography |
| Editing | William Austin | Editor |
| Art | John B. Goodman | Art Direction |
| Art | Martin Obzina | Art Direction |
| Art | Russell A. Gausman | Set Decoration |
| Art | Edward R. Robinson | Set Decoration |
| Costume & Make-Up | Vera West | Costume Design |
| Sound | Bernard B. Brown | Sound Director |
| Sound | Hans J. Salter | Music Director |
| Writing | Arthur Conan Doyle | Story |
