Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing.
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| Directing | David Cronenberg | Director |
| Camera | Peter Suschitzky | Director of Photography |
| Writing | William S. Burroughs | Novel |
| Sound | Howard Shore | Original Music Composer |
| Visual Effects | Chris Walas | Creature Design |
| Sound | David Evans | Sound Effects Editor |
| Costume & Make-Up | Brenda Gilles | Costume Supervisor |
| Costume & Make-Up | Christine Hart | Makeup Department Head |
| Sound | Don White | Sound Re-Recording Mixer |
| Sound | Peter Maxwell | Sound Re-Recording Mixer |
| Sound | Jane Tattersall | Sound Effects Editor |
| Sound | David Appleby | Sound Re-Recording Mixer |
| Writing | David Cronenberg | Writer |
| Production | Gabriella Martinelli | Co-Producer |
| Editing | Ronald Sanders | Editor |
| Sound | Ornette Coleman | Original Music Composer |
| Art | Carol Spier | Production Design |
| Art | Elinor Rose Galbraith | Set Decoration |
| Production | Jeremy Thomas | Producer |
| Production | Deirdre Bowen | Casting |
| Art | James McAteer | Art Direction |
| Costume & Make-Up | Denise Cronenberg | Costume Design |
| Costume & Make-Up | Rhoda Ancill | Hairstylist |
| Costume & Make-Up | Marilyn O'Quinn | Assistant Makeup Artist |
| Costume & Make-Up | Judy Murdock | Assistant Makeup Artist |
| Costume & Make-Up | Veronica Ciandre | Hairstylist |
| Costume & Make-Up | Carmen MacDonald | Hairstylist |
| Costume & Make-Up | Lucy M. Orton | Hairstylist |
| Costume & Make-Up | Marlene Aarons | Assistant Makeup Artist |
| Sound | Bryan Day | Sound Mixer |
