Having lost their status and credibility five years after covering New York City with gooey roasted marshmallows in Ghostbusters (1984), the city's former heroes and once-popular spirit-hunters struggle to keep afloat, forced to work odd jobs. However, when Dana and her baby have yet another terrifying encounter with the paranormal, it is up to Peter Venkman and his fearless team of supernatural crime fighters to step up and save the day. Once more, humankind is in danger, as rivers of slimy psycho-reactive ectoplasm, paired with the dreadful manifestation of evil sixteenth-century tyrant Vigo the Carpathian, threaten to plunge the entire city into darkness. Is the world ready to believe? Can the Ghostbusters save us for the second time?
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| Sound | Randy Edelman | Original Music Composer |
| Writing | Harold Ramis | Screenplay |
| Production | Ivan Reitman | Producer |
| Writing | Dan Aykroyd | Screenplay |
| Camera | Michael Chapman | Director of Photography |
| Crew | Danny Aiello III | Stunts |
| Directing | Ivan Reitman | Director |
| Crew | Billy D. Lucas | Stunts |
| Crew | Jon Curtis Price | Special Effects |
| Crew | Lane Leavitt | Stunts |
| Crew | Steven Lambert | Stunts |
| Crew | Richard E. Butler | Stunts |
| Costume & Make-Up | John Dods | Makeup Artist |
| Crew | Bob Minor | Stunts |
| Costume & Make-Up | Frank Bianco | Hairstylist |
| Art | Richard Hoffenberg | Construction Foreman |
| Editing | Chris Jargo | Dialogue Editor |
| Sound | Tom C. McCarthy | Supervising Sound Editor |
| Directing | Faye Brenner | Script Supervisor |
| Editing | Sheldon Kahn | Editor |
| Production | Michael Chinich | Casting |
| Costume & Make-Up | John M. Elliott Jr. | Key Makeup Artist |
| Costume & Make-Up | Peggy Semtob | Hairstylist |
| Production | Pamela Cederquist | Production Coordinator |
| Art | Bo Welch | Production Design |
| Crew | Erik Cord | Stunts |
| Sound | Bruce Foster | Sound Editor |
| Art | Tom Duffield | Art Direction |
| Art | Cheryl Carasik | Set Decoration |
| Costume & Make-Up | Gandhi Bob Arrollo | Makeup Artist |
| Editing | Donn Cambern | Editor |
| Costume & Make-Up | Marlene D. Williams | Hairstylist |
| Directing | Peter Giuliano | First Assistant Director |
| Sound | Don S. Walden | Sound Editor |
| Costume & Make-Up | Stephen Abrums | Makeup Artist |
| Sound | David M. Ice | Sound Editor |
| Costume & Make-Up | Gloria Gresham | Costume Design |
| Art | Nick Navarro | Set Designer |
| Crew | Joel Kramer | Stunt Coordinator |
| Sound | Richard Friedman | Supervising ADR Editor |
| Camera | Michael Genne | Camera Operator |
| Lighting | Leslie J. Kovacs | Chief Lighting Technician |
| Camera | Bruce McBroom | Still Photographer |
| Costume & Make-Up | G. Tony Scarano | Costume Supervisor |
| Sound | Burton Weinstein | Sound Editor |
| Visual Effects | Pamela Easley | Visual Effects Coordinator |
| Camera | Robert Edesa | Camera Operator |
| Sound | Peter Afterman | Music Supervisor |
| Art | Bill MacSems | Property Master |
| Crew | Ed Mirassou | Propmaker |
| Art | William A. Petrotta | Property Master |
| Crew | Jo Martin | Visual Effects Editor |
| Art | Greg John Callas | Construction Coordinator |
| Visual Effects | Janet Healy | Visual Effects Producer |
| Sound | Fred Judkins | Supervising Sound Editor |
| Visual Effects | Dennis Muren | Visual Effects Supervisor |
| Costume & Make-Up | Oda Groeschel | Costume Supervisor |
| Art | Rick Heinrichs | Set Designer |
| Art | Greg Papalia | Set Designer |
| Sound | Steve Cantamessa | Boom Operator |
| Sound | Solange S. Schwalbe | Sound Editor |
| Crew | Kurt Bryant | Stunts |
| Crew | Jophery C. Brown | Stunts |
| Writing | Harold Ramis | Characters |
| Writing | Dan Aykroyd | Characters |
| Art | Edmund E. Villa | Assistant Property Master |
| Crew | Tony Brubaker | Stunt Double |
| Crew | Andy Gill | Stunts |
| Crew | Gary J. Wayton | Stunt Double |
| Crew | Debbie Evans | Stunts |
| Crew | Wally Crowder | Stunts |
| Crew | Bill Anagnos | Stunts |
| Crew | Peter Bucossi | Stunts |
| Crew | Roger Creed | Stunts |
| Crew | Leon Delaney | Stunts |
| Crew | Lori Crowder | Stunts |
| Crew | Leah Creed | Stunts |
| Crew | Frank Ferrara | Stunts |
| Crew | Marguerite Happy | Stunts |
| Crew | Donna Garrett | Stunts |
| Crew | Clifford Happy | Stunts |
| Crew | Michael Russo | Stunts |
| Crew | Kerrie Cullen | Stunts |
| Crew | Gene Harrison | Stunts |
| Crew | Mick O'Rourke | Stunts |
| Crew | Anthony G. Schmidt | Stunts |
| Crew | Deborah Watkins | Stunts |
| Crew | Roydon Clark | Stunts |
| Crew | Kym Washington Longino | Stunts |
| Crew | Sven-Ole Thorsen | Stunts |
| Crew | Jery Hewitt | Stunts |
| Crew | Phil Neilson | Stunts |
| Crew | Paula Wayton | Stunts |
| Crew | John Robotham | Stunts |
| Crew | Sandy Richman | Stunts |
| Crew | Ceci Vendrell | Stunts |
| Crew | Fred Lerner | Stunts |
| Crew | Michael M. Vendrell | Stunts |
| Crew | Frank James Sparks | Stunts |
| Crew | William T. Lane | Stunts |
| Crew | Larry Holt | Stunts |
| Crew | David Webster | Stunts |
| Crew | Vince Deadrick Sr. | Stunts |
| Directing | Sue Fellows | Assistant Director Trainee |
| Production | Dorothy O'Leary | Casting Assistant |
| Camera | Gene Kearney | Key Grip |
| Art | Tom Miller | Assistant Property Master |
| Lighting | E. Christopher Reed | Electrician |
| Lighting | Gregory Peters | Electrician |
| Costume & Make-Up | Jennifer Butler | Costumer |
| Lighting | Benny McNulty | Best Boy Electrician |
| Camera | Bob Muñoz | Best Boy Grip |
| Crew | Chuck Gaspar | Special Effects |
| Lighting | Ken W. Ballantine | Electrician |
| Costume & Make-Up | Le Dawson | Costumer |
| Art | Ann Harmon | Art Department Assistant |
| Lighting | Eric Smith | Electrician |
| Costume & Make-Up | Adrienne Manhan | Costumer |
| Lighting | Brent Poe | Electrician |
| Camera | Sandy Williams | Dolly Grip |
| Sound | Greig McRitchie | Orchestrator |
| Directing | Cyd Adams | Second Second Assistant Director |
| Production | Stephanie Kahn | Production Assistant |
| Production | David Forbes | Production Assistant |
| Crew | Richard Wood | Special Effects |
| Sound | Mark Gordon | Sound Editor |
| Crew | Mark Jennings | Cableman |
| Sound | William Hartman | Sound Editor |
| Directing | Ira S. Rosenstein | Second Second Assistant Director |
| Production | Jim Vatis | Production Assistant |
| Sound | Gene S. Cantamessa | Production Sound Mixer |
| Production | Stuart Fink | Publicist |
| Camera | Robert Sordal | Dolly Grip |
| Crew | Dick Johnson | Transportation Captain |
| Crew | Joe Day | Special Effects |
| Crew | Craig Pinkard | Transportation Coordinator |
| Production | Gaetano Vaccaro | Production Assistant |
| Production | Ginny Warner | Production Secretary |
| Production | Anne Prager | Production Assistant |
| Art | Francis N. 'Lucky' Costello | Standby Painter |
| Production | Matthew Gould | Production Assistant |
| Production | Catherine Cederquist | Production Assistant |
| Production | Bernie Brillstein | Executive Producer |
| Production | Gordon A. Webb | Unit Production Manager |
| Camera | Greg Walters | Second Assistant Camera |
| Art | Chuck McSorley | Leadman |
| Art | Jack Johnson | Production Illustrator |
| Camera | Larry Hezzelwood | First Assistant Camera |
| Production | Joe Medjuck | Executive Producer |
| Camera | Tim Sasaki | Second Assistant Camera |
| Production | Sheldon Kahn | Associate Producer |
| Camera | Dylan Goss | Camera Loader |
| Production | Michael C. Gross | Executive Producer |
| Directing | Christine Larson-Nitzsche | Second Assistant Director |
| Directing | Michael D. Moore | Second Unit Director |
| Art | Thom Enriquez | Production Illustrator |
| Art | John Warnke | Assistant Art Director |
| Production | Gordon A. Webb | Associate Producer |
| Crew | Mary Peters | Stunts |
