Dr. Lily Houghton enlists the aid of wisecracking skipper Frank Wolff to take her down the Amazon in his dilapidated boat. Together, they search for an ancient tree that holds the power to heal – a discovery that will change the future of medicine.
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| Crew | Lauren Shaw | Utility Stunts |
| Crew | Nicole Vela-Bailey | Stunts |
| Crew | Erika Takacs | Stunts |
| Crew | Suzanne Reed | Stunts |
| Crew | Allan Poppleton | Stunt Coordinator |
| Crew | Stacey Carino | Stunts |
| Crew | Maya Santandrea | Stunts |
| Crew | Alice Rietveld | Stunt Double |
| Crew | Zoey Chang | Stunts |
| Crew | Lauren Shaw | Stunt Double |
| Crew | Hannah Betts | Stunts |
| Crew | Lauren Shaw | Stunt Driver |
| Crew | Adrienne Ballenger | Stunt Double |
| Crew | Adrienne Ballenger | Stunts |
| Crew | Bonnie Campanella | Stunts |
| Crew | Maya Santandrea | Utility Stunts |
| Crew | Hannah Betts | Utility Stunts |
| Crew | Kelly Bellini | Stunts |
| Crew | Hannah Betts | Stunt Double |
| Production | Beau Flynn | Producer |
| Production | Dwayne Johnson | Producer |
| Writing | John Requa | Screenplay |
| Writing | John Norville | Screenstory |
| Writing | Glenn Ficarra | Screenplay |
| Sound | James Newton Howard | Original Music Composer |
| Production | Scott Sheldon | Executive Producer |
| Editing | Joel Negron | Editor |
| Writing | John Requa | Screenstory |
| Writing | Josh Goldstein | Screenstory |
| Writing | Michael Green | Screenplay |
| Production | Riley Flanagan | Key Set Production Assistant |
| Art | David Lazan | Supervising Art Director |
| Art | Stella Vaccaro | Art Direction |
| Art | Gregory S. Hooper | Art Direction |
| Art | Larry Dias | Set Decoration |
| Art | Nic Pallace | Art Direction |
| Art | Chris Hansen | Art Direction |
| Art | Thomas P. Wilkins | Art Direction |
| Art | Dean Wolcott | Art Direction |
| Art | Leslie McDonald | Art Direction |
| Art | Drew Monahan | Art Direction |
| Sound | Malte Bieler | Sound Editor |
| Sound | Matt Cavanaugh | Sound Effects Editor |
| Visual Effects | Viktor Müller | Visual Effects Supervisor |
| Sound | Erik Aadahl | Supervising Sound Editor |
| Sound | Goeun Lee Everett | Sound Effects Editor |
| Sound | Ethan Van der Ryn | Supervising Sound Editor |
| Visual Effects | Stephane Paris | Visual Effects Supervisor |
| Costume & Make-Up | Jordann Aguon | Makeup Artist |
| Sound | Ralph Osborn | Dialogue Editor |
| Sound | Aaron Southerland | ADR Mixer |
| Sound | Erik Aadahl | Sound Designer |
| Sound | Willard Overstreet | Foley Editor |
| Visual Effects | Christopher Downs | Visual Effects Supervisor |
| Sound | Dan O'Connell | Foley Artist |
| Visual Effects | Gaia Bussolati | Visual Effects Supervisor |
| Sound | Kevin Cerchiai | Boom Operator |
| Sound | Brandon Jones | Sound Designer |
| Sound | Stuart Welch | ADR Recordist |
| Visual Effects | Jim Berney | Visual Effects Supervisor |
| Visual Effects | John Knoll | Visual Effects Supervisor |
| Sound | Lee Gilmore | Sound Effects Editor |
| Sound | Ethan Van der Ryn | Sound Designer |
| Sound | Ron Bartlett | Sound Re-Recording Mixer |
| Sound | Greg ten Bosch | Sound Effects Editor |
| Sound | Ignacio Arrojo | ADR Recordist |
| Sound | Ian Bender | Boom Operator |
| Sound | Hunter Berk | ADR Mixer |
| Sound | Jack Cucci | Foley Mixer |
| Sound | Joel Erickson | ADR Supervisor |
| Sound | Jason Oliver | ADR Mixer |
| Sound | Victor Mercader | Sound Editor |
| Visual Effects | Luke Millar | Visual Effects Supervisor |
| Visual Effects | Jake Morrison | Visual Effects Supervisor |
| Costume & Make-Up | Laura Aguon | Makeup Artist |
| Sound | Robert Jackson | Dialogue Editor |
| Sound | John Marquis | Sound Designer |
| Costume & Make-Up | Derek Garcia | Makeup Artist |
| Costume & Make-Up | Natalie Bruce | Makeup Artist |
| Costume & Make-Up | Addison Foreman | Makeup Artist |
| Costume & Make-Up | Chris Diamantides | Makeup Artist |
| Costume & Make-Up | Devin Shayla Morales | Makeup Artist |
| Costume & Make-Up | Merc Arceneaux | Makeup Artist |
| Costume & Make-Up | Melody Levy | Makeup Artist |
| Costume & Make-Up | Jordan Venetis | Makeup Artist |
| Costume & Make-Up | Aida Scuffle | Makeup Artist |
| Costume & Make-Up | Ozzy Alvarez | Makeup Artist |
| Costume & Make-Up | Karen Iboshi Preiser | Makeup Artist |
| Costume & Make-Up | Rachel Bongard | Makeup Artist |
| Costume & Make-Up | André Freitas | Makeup Artist |
| Costume & Make-Up | Matt Sprunger | Makeup Artist |
| Costume & Make-Up | Mark James Ross | Makeup Artist |
| Visual Effects | Michael Furniss | Visual Effects |
| Crew | Matt Leonard | Stunts |
| Visual Effects | Kay Hoddy | Rotoscoping Artist |
| Costume & Make-Up | Adruitha Lee | Hair Department Head |
| Sound | Michael B. Koff | Sound Mixer |
| Production | Douglas C. Merrifield | Unit Production Manager |
| Production | Marisol Roncali | Casting Director |
| Art | Nathan Krochmal | Assistant Art Director |
| Crew | Greg Tresan | Animal Wrangler |
| Visual Effects | Marla Neto Henshaw | Visual Effects Producer |
| Visual Effects | Amber Kirsch | Visual Effects Producer |
| Costume & Make-Up | Joel Harlow | Makeup Department Head |
| Visual Effects | Sarah Stauffer | Visual Effects Coordinator |
| Art | Margaret Hungerford | Assistant Set Decoration |
| Directing | David H. Venghaus Jr. | First Assistant Director |
| Production | David H. Venghaus Jr. | Associate Producer |
| Costume & Make-Up | Kimberly Felix | Key Makeup Artist |
| Visual Effects | Andy Taylor | Visual Effects Producer |
| Production | Mary Vernieu | Casting Director |
| Production | Petra Holtorf | Co-Producer |
| Directing | Eric Richard Lasko | Second Assistant Director |
| Costume & Make-Up | Vanessa Davis | Key Hair Stylist |
| Directing | Anna Rane | Script Supervisor |
| Crew | Carol Tresan | Animal Wrangler |
| Sound | David Olson | Music Editor |
| Production | Larry Franco | Consulting Producer |
| Sound | Jeanette Surga | Supervising Music Editor |
| Crew | Eric Cook | Special Effects Coordinator |
| Visual Effects | Paul Ramsden | Animation Supervisor |
| Visual Effects | J.D. Schwalm | Special Effects Supervisor |
| Sound | Jim Weidman | Music Editor |
| Production | Lacey Darlene Paulson | Associate Producer |
| Production | Robert Mazaraki | Production Supervisor |
| Art | Kristen Nowotarski | Assistant Art Director |
| Production | Marc Zakalik | Production Coordinator |
| Crew | David Conley | Executive Visual Effects Producer |
| Visual Effects | David Gullman | Visual Effects Coordinator |
| Visual Effects | Peter Calvillo | Visual Effects Coordinator |
| Visual Effects | Mare McIntosh | Visual Effects Production Manager |
| Visual Effects | Reetu Aggarwal | 3D Artist |
| Art | Kevin Houlihan | Set Designer |
| Directing | Jaume Collet-Serra | Director |
| Directing | Alexander Witt | Second Unit Director |
| Production | Hiram Garcia | Producer |
| Production | John Fox | Producer |
| Art | Jean-Vincent Puzos | Production Design |
| Costume & Make-Up | Paco Delgado | Costume Design |
| Camera | Flavio Martínez Labiano | Director of Photography |
| Production | Dany Garcia | Producer |
| Production | Douglas C. Merrifield | Executive Producer |
| Production | John Davis | Producer |
| Crew | John C. Meier | Stunts |
| Visual Effects | Keita Hoshino | Compositing Artist |
| Crew | Shawn Kautz | Stunts |
| Crew | John Gilbert | Utility Stunts |
| Crew | Nico Woulard | Stunts |
| Crew | Anthony N. | Stunts |
| Crew | Tony Vittorioso | Stunts |
| Crew | Tanoai Reed | Stunt Double |
| Crew | Thomas Robinson Harper | Stunts |
| Crew | Nick Epper | Stunts |
| Crew | Sala Baker | Stunts |
| Crew | George Quinones | Stunts |
| Crew | Kris A. Jeffrey | Stunts |
| Crew | Robert Tinsley | Stunts |
| Crew | Dario Perez | Stunts |
| Crew | Brian L. Keaulana | Stunts |
| Crew | Isaac Hughes | Stunts |
| Crew | Remington Steele | Stunts |
| Crew | Darin Fujimori | Stunts |
| Crew | Mike Rufino | Stunts |
| Crew | Nick Stanner | Stunts |
| Crew | Thom Williams | Stunts |
| Crew | Marcus Young | Stunts |
| Crew | Kent De Mond | Stunts |
| Crew | Tyler Witte | Stunts |
| Crew | Nikolas Pelekai | Stunts |
| Crew | Gary Price | Stunts |
| Crew | Steve Upton | Utility Stunts |
| Crew | Jason A. Triplett | Stunts |
| Art | Justin Trudeau | Set Designer |
| Costume & Make-Up | Stacy Horn | Costume Supervisor |
| Visual Effects | Joe Howes | Visual Effects |
| Crew | Tim McGovern | Digital Effects Supervisor |
| Art | Robert Fechtman | Set Designer |
| Visual Effects | Chad Wiebe | Visual Effects Supervisor |
| Writing | Glenn Ficarra | Screenstory |
| Sound | Holly Sedillos | Vocals |
| Crew | Travis Gomez | Stunts |
