When Van Helsing's mysterious invention, the "Monsterfication Ray," goes haywire, Drac and his monster pals are all transformed into humans, and Johnny becomes a monster. In their new mismatched bodies, Drac and Johnny must team up and race across the globe to find a cure before it's too late, and before they drive each other crazy.
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| Editing | Lynn Hobson | Editor |
| Art | Richard Daskas | Production Design |
| Writing | Genndy Tartakovsky | Story |
| Writing | Amos Vernon | Screenplay |
| Writing | Nunzio Randazzo | Screenplay |
| Writing | Genndy Tartakovsky | Screenplay |
| Art | David Feiss | Main Title Designer |
| Visual Effects | Craig Kellman | Character Designer |
| Sound | Mark Mothersbaugh | Original Music Composer |
| Crew | Chad Ellis | Supervising Animator |
| Crew | Toby Pedersen | Supervising Animator |
| Crew | Genevieve West | Digital Producer |
| Production | Alan Hawkins | Associate Producer |
| Crew | Dylan Gottlieb | CG Supervisor |
| Camera | Tom Bruno Jr. | Head of Layout |
| Crew | Adam Sarophim | Supervising Animator |
| Crew | Sam Verschraegen | Supervising Animator |
| Production | Scott Berri | Production Manager |
| Crew | Mitchell Yager | Supervising Animator |
| Visual Effects | Dylan Reid | Animation Supervisor |
| Crew | Chelsea Gordon-Ratzlaff | Supervising Animator |
| Art | Michael Isaak | Art Direction |
| Crew | Jeff Panko | Supervising Animator |
| Production | Ryan Gilleland | Co-Producer |
| Crew | Katherine Renee Jones | CG Supervisor |
| Visual Effects | Seth Maury | Visual Effects Supervisor |
| Crew | Sang Uk Park | Supervising Animator |
| Crew | Jim McLean | CG Supervisor |
| Crew | Andres Bedate Martin | Supervising Animator |
| Crew | Kelsey Wagner | Supervising Animator |
| Crew | Joe Viola | CG Supervisor |
| Sound | Ryan A. Sullivan | Sound Effects Editor |
| Production | Selena Gomez | Executive Producer |
| Directing | Jennifer Kluska | Director |
| Directing | Derek Drymon | Director |
| Production | Alice Dewey | Producer |
| Production | Michelle Murdocca | Executive Producer |
| Production | Genndy Tartakovsky | Executive Producer |
