A large spider from the jungles of South America is accidentally transported in a crate with a dead body to America where it mates with a local spider. Soon after, the residents of a small California town disappear as the result of spider bites from the deadly spider offspring. It's up to a couple of doctors with the help of an insect exterminator to annihilate these eight legged freaks.
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| Production | Kathleen Kennedy | Producer |
| Sound | Trevor Jones | Original Music Composer |
| Directing | Frank Marshall | Director |
| Writing | Don Jakoby | Screenplay |
| Production | Frank Marshall | Executive Producer |
| Production | Steven Spielberg | Executive Producer |
| Writing | Wesley Strick | Screenplay |
| Camera | Mikael Salomon | Director of Photography |
| Production | Richard Vane | Producer |
| Editing | Michael Kahn | Editor |
| Crew | Robert 'Bobby Z' Zajonc | Pilot |
| Art | Ernie Depew | Construction Coordinator |
| Production | Valorie Massalas | Casting |
| Camera | Eric J. Goldstein | Camera Operator |
| Writing | Don Jakoby | Story |
| Sound | Ron Judkins | Sound Mixer |
| Camera | Bobby Huber | Key Grip |
| Production | Don Jakoby | Co-Producer |
| Production | Judy Taylor | Casting |
| Directing | Bruce Cohen | First Assistant Director |
| Directing | David D'Ovidio | Second Assistant Director |
| Art | Suzanne Lee Peck | Art Department Coordinator |
| Costume & Make-Up | David Quashnick | Makeup Artist |
| Camera | Rebecca Baehler | Camera Loader |
| Crew | Randy McDonald | Cableman |
| Art | Christopher Burian-Mohr | Art Direction |
| Directing | Julie Pitkanen | Script Supervisor |
| Art | Max E. Brehme | Set Dresser |
| Crew | Richmond G. Cogswell | Video Assist Operator |
| Art | Tim Donelan | Leadman |
| Camera | David Luckenbach | Second Assistant Camera |
| Sound | Tom C. McCarthy | Supervising Sound Editor |
| Art | James D. Bissell | Production Design |
| Production | William S. Beasley | Unit Production Manager |
| Crew | Chuck Waters | Stunt Coordinator |
| Art | Don Kaeding | Set Dresser |
| Camera | Ian Fox | First Assistant Camera |
| Lighting | Dwight Campbell | Gaffer |
| Camera | Jimmy Leavens | Dolly Grip |
| Sound | Tom Carlson | Music Editor |
| Costume & Make-Up | James Lee McCoy | Makeup Artist |
| Costume & Make-Up | Dione Taylor | Hairstylist |
| Camera | Jesse Chavez | Best Boy Grip |
| Visual Effects | Alison Savitch | Visual Effects Coordinator |
| Crew | Randy Burke | Transportation Captain |
| Art | Edward T. McAvoy | Assistant Art Director |
| Art | Louis S. Fleming | Property Master |
| Art | Gus Feederle | Assistant Property Master |
| Art | Mike Carrillo | Set Dresser |
| Art | Gary F. Kieldrup | Assistant Property Master |
| Art | Jackie Carr | Set Decoration |
| Camera | Ralph Nelson Jr. | Still Photographer |
| Production | Mike Fenton | Casting |
| Costume & Make-Up | Carolyn Elias | Hairstylist |
| Costume & Make-Up | Jennifer L. Parsons | Costume Design |
| Sound | R.J. Kizer | Supervising ADR Editor |
| Visual Effects | Matt Sweeney | Special Effects Supervisor |
| Production | Barbara Harris | ADR Voice Casting |
| Sound | Richard Friedman | Supervising ADR Editor |
| Camera | Jack Glenn | Grip |
| Crew | Dan Marrow | Transportation Coordinator |
| Editing | Stephen R. Sheridan | Color Timer |
| Camera | Paul Iski | Grip |
| Visual Effects | David Sosalla | Visual Effects Supervisor |
| Crew | Marsha Robertson | Unit Publicist |
| Sound | Robert Jackson | Boom Operator |
| Sound | David J. Hudson | Sound Re-Recording Mixer |
| Sound | Terry Porter | Sound Re-Recording Mixer |
| Sound | Mel Metcalfe | Sound Re-Recording Mixer |
| Sound | Hilda Hodges | Foley Artist |
| Editing | Gary Burritt | Negative Cutter |
| Visual Effects | Chris Walas | Creature Effects Technical Director |
| Production | Ted Field | Co-Executive Producer |
| Production | Robert W. Cort | Co-Executive Producer |
| Production | William S. Beasley | Associate Producer |
| Crew | Spice Williams-Crosby | Stunts |
| Writing | Al Williams | Story |
