Pushed to the breaking-up point after their latest 'why can't you do this one little thing for me?' argument, Brooke calls it quits with her boyfriend Gary. What follows is a hilarious series of remedies, war tactics, overtures and undermining tricks – all encouraged by the former couple's friends and confidantes …and the occasional total stranger! When neither ex is willing to move out of their shared apartment, the only solution is to continue living as hostile roommates until one of them reaches breaking point.
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| Writing | Jeremy Garelick | Screenplay |
| Production | Scott Stuber | Producer |
| Writing | Vince Vaughn | Story |
| Production | Peter Billingsley | Executive Producer |
| Writing | Jeremy Garelick | Story |
| Editing | Dan Lebental | Editor |
| Editing | David Rosenbloom | Editor |
| Camera | Eric Alan Edwards | Director of Photography |
| Writing | Jay Lavender | Story |
| Writing | Jay Lavender | Screenplay |
| Directing | Peyton Reed | Director |
| Production | Stuart M. Besser | Executive Producer |
| Production | Vince Vaughn | Producer |
| Production | John Isbell | Associate Producer |
| Production | Jeremy Garelick | Co-Producer |
| Production | Victoria Vaughn | Associate Producer |
| Production | Jay Lavender | Co-Producer |
| Crew | Troy Gilbert | Stunts |
| Crew | Linda Perlin | Stunts |
| Crew | Lance Gilbert | Stunts |
| Production | Juel Bestrop | Casting |
| Production | Jeanne McCarthy | Casting |
| Art | Andrew Laws | Production Design |
| Costume & Make-Up | Carol Oditz | Costume Design |
| Sound | John O'Brien | Music Supervisor |
| Camera | Jody Williams | "B" Camera Operator |
| Camera | Joe Carpita | Camera Loader |
| Costume & Make-Up | Joyce Kogut | Costume Supervisor |
| Costume & Make-Up | Annie Laoparadonchai | Costumer |
| Costume & Make-Up | Suzi Ostos | Makeup Department Head |
| Art | Daniel B. Clancy | Set Decoration |
| Sound | John Pritchett | Production Sound Mixer |
| Camera | Fred Folmer | Dolly Grip |
| Crew | John D. Milinac | Special Effects Coordinator |
| Costume & Make-Up | Ellen Ryba | Assistant Costume Designer |
| Sound | Kimberly Harris | Supervising ADR Editor |
| Production | Barry Barclay | Production Coordinator |
| Crew | Sean T. Stratton | Post Production Supervisor |
| Sound | Cameron Frankley | Sound Supervisor |
| Sound | David Williams | Dialogue Editor |
| Production | Jaime Harlan | Casting Assistant |
| Production | Jonathan Kinnas | Extras Casting |
| Sound | Jon Michaels | First Assistant Sound Editor |
| Art | Paul Meylink | Storyboard Artist |
| Production | Stacy Laiderman | Art Department Production Assistant |
| Camera | Peter Kuttner | First Assistant "A" Camera |
| Directing | Sheila Waldron | Script Supervisor |
| Directing | Todd Amateau | First Assistant Director |
| Art | Brian Cho | Art Department Coordinator |
| Camera | Colin Slaby | Second Assistant "A" Camera |
| Sound | David M. Roberts | Boom Operator |
| Art | William D'Ambra | Property Master |
| Lighting | James F. Roorda | Key Rigging Grip |
| Costume & Make-Up | Alyssa Kim | Costumer |
| Directing | Nina Jack | Second Assistant Director |
| Art | Marco Rubeo | Assistant Art Director |
| Art | Stephanie Gilliam | Set Designer |
| Art | David J. Chamerski | Assistant Property Master |
| Costume & Make-Up | Nancy Cavallaro | Set Costumer |
| Costume & Make-Up | Jane Blank | Seamstress |
| Costume & Make-Up | Angela Levin | Makeup Artist |
| Production | Mitchell E. Dauterive | Production Supervisor |
| Art | Scott Troha | Leadman |
| Camera | John Hudecek | Dolly Grip |
| Production | Al Nolan-Cohn | Location Manager |
| Directing | Anthony J. Nahar | Second Second Assistant Director |
| Costume & Make-Up | Terry Anderson | Assistant Costume Designer |
| Costume & Make-Up | Gina Marie Ome | Key Costumer |
| Camera | Paul DeMarte | First Assistant "B" Camera |
| Lighting | Dick Oakes | Gaffer |
| Camera | Melissa Moseley | Still Photographer |
| Crew | Lisa Gillespie | Cableman |
| Camera | Art Bartels | Key Grip |
| Costume & Make-Up | Thomas J. Glynn | On Set Dresser |
| Camera | Greg Jackson | Second Assistant "B" Camera |
| Lighting | Robert Swander | Best Boy Electric |
| Production | Patrick Muldoon | Assistant Location Manager |
| Costume & Make-Up | Jacqueline S. Beatka | Set Costumer |
| Costume & Make-Up | Chris McMillan | Hairstylist |
| Costume & Make-Up | Tony Mirante | Assistant Hairstylist |
| Sound | Ulrika Akander | Supervising Dialogue Editor |
| Production | Jennifer Rudnicke | Local Casting |
| Crew | Michael P. Deal | Transportation Captain |
| Lighting | Chris Mulsoff | Rigging Gaffer |
| Costume & Make-Up | Nina Hallworth | Costume Designer |
| Crew | Thaddeus E. Larkowski | Transportation Coordinator |
| Production | Joseph Hicks | Extras Casting |
| Production | Ruth Goff | Extras Casting |
| Production | Lori Scowley | Production Accountant |
| Production | Tracy Dixon | Extras Casting |
| Production | Mickie Paskal | Local Casting |
| Production | Seth Yanklewitz | Casting Associate |
| Production | Andrew Blau | Production Coordinator |
| Production | Paula Stier | Production Secretary |
| Sound | Cameron Frankley | Sound Designer |
| Sound | David V. Butler | Dialogue Editor |
| Crew | Joe Bucaro III | Stunt Coordinator |
| Art | David Sandefur | Art Direction |
| Camera | Peter Rosenfeld | Steadicam Operator |
| Production | Martha Lafage | Assistant Location Manager |
| Production | Elicia Zimmerman | Location Coordinator |
| Production | Stuart M. Besser | Unit Production Manager |
| Camera | Peter Rosenfeld | "A" Camera Operator |
| Camera | George Kohut | "B" Camera Operator |
| Camera | Jody Williams | Second Unit Director of Photography |
| Editing | Richmond Riedel | Assistant Editor |
| Sound | Teri E. Dorman | Dialogue Editor |
| Camera | Don Miller | Best Boy Grip |
| Art | Maria C. Roxas | Location Scout |
| Costume & Make-Up | Dominic Mango | Hair Department Head |
| Editing | Gregory Plotkin | First Assistant Editor |
| Editing | Sandra Torres Granovsky | First Assistant Editor |
| Crew | Darnell Jones | Transportation Co-Captain |
| Sound | Linda Folk | ADR Editor |
| Art | Bruce DiValerio | Construction Coordinator |
| Sound | Doc Kane | ADR Mixer |
| Sound | Rick Canelli | ADR Recordist |
| Editing | Gary Burritt | Negative Cutter |
| Sound | Randy Kelley | Sound Effects Editor |
| Sound | Steve Pederson | Sound Re-Recording Mixer |
| Sound | Thomas J. O'Connell | ADR Mixer |
| Sound | Scott Curtis | Foley Editor |
| Sound | Steve Bartek | Conductor |
| Sound | Christopher Flick | Foley Editor |
| Sound | Jonathan Karp | Music Editor |
| Sound | Steve Bartek | Orchestrator |
| Sound | Alicia Stevenson | Foley Artist |
| Sound | Brad Sherman | Sound Re-Recording Mixer |
| Sound | Jeanette Browning | ADR Recordist |
| Sound | Kevin Warendorp | Assistant Sound Editor |
| Sound | Dawn Fintor | Foley Artist |
| Production | Barbara Harris | ADR Voice Casting |
| Sound | Ai-Ling Lee | Sound Effects Editor |
| Sound | David Betancourt | Foley Mixer |
| Sound | Jason W. Jennings | Sound Effects Editor |
| Sound | Jon Brion | Original Music Composer |
| Costume & Make-Up | Clare Hallworth | Costume Design |
| Costume & Make-Up | Chelo Ontiveros | Key Makeup Artist |
| Lighting | Noah Banks | Lighting Technician |
| Editing | Olivia Giachino | Editorial Production Assistant |
| Costume & Make-Up | Lisa Jelic | Makeup Artist |
| Crew | Brigitte Bourque | Compositor |
| Lighting | Jaime Dawkins | Rigging Grip |
| Crew | Assata Amoaku | Craft Service |
| Editing | Mike Kennedy | Digital Intermediate Producer |
| Camera | Louisa McHugh | Camera Intern |
| Crew | Nathaniel E. Bell | Set Production Assistant |
| Visual Effects | Heather Elisa Hill | Visual Effects Coordinator |
| Crew | Virginia Landis Albertson | Post Production Supervisor |
| Camera | Steven R. Wojcik | Additional Camera |
| Production | Gail Rose | Post Production Accountant |
| Directing | Cara Giallanza | Assistant Director |
| Crew | Steve Hull | Carpenter |
| Sound | Eric Flickinger | Sound Recordist |
| Crew | Joe Andaloro | Stand In |
| Crew | Kym Washington Longino | Stunt Double |
| Editing | Stacey Frederick | Assistant Editor |
| Crew | John M. Pisani | Unit Publicist |
| Crew | Michael T. Brady | Stunts |
| Art | Terry Baughman | Construction Foreman |
| Editing | Jim Passon | Color Timer |
| Art | Kyle Holden | Props |
| Sound | Kirk Francis | Sound Mixer |
| Lighting | Chad Catuara | Electrician |
| Production | Donald Fly | General Manager |
| Costume & Make-Up | Patrick Caulfield | Key Set Costumer |
| Camera | George Kohut | Camera Operator |
| Crew | Frank Battaglia | Special Effects Technician |
| Camera | Eric Wheeler | Assistant Camera |
| Production | Jeremy Beiermann | Assistant Production Coordinator |
| Production | Crista Birgy | First Assistant Accountant |
| Camera | E.J. Huntemann | Grip |
| Production | Mike Doto | Production Manager |
| Visual Effects | Thomas J. Smith | Visual Effects Supervisor |
| Costume & Make-Up | Erika Walthall | Costume Assistant |
| Production | Nick Rafferty | Location Assistant |
| Production | Timber Kislan | Payroll Accountant |
| Art | Veloz Gomez | Set Dresser |
| Sound | Dan Guachione | Boom Operator |
| Sound | Jackie Gleason | Musician |
| Crew | Michael R. Cairo | Driver |
| Production | Alex Cohn | Location Manager |
| Camera | Joe Gajewski | Additional Grip |
| Sound | Jon Michaels | Assistant Sound Editor |
| Crew | John J. Slove Jr. | Propmaker |
| Production | Jennifer Webb | Travel Coordinator |
| Camera | David Norris | Aerial Director of Photography |
| Crew | Marijan 'Mario' Zoric | Chef |
| Art | David E. Scott | Graphic Designer |
| Art | Matt Reitsma | Textile Artist |
| Production | Lindsay Heller | Extras Casting Assistant |
| Editing | Donnie Creighton | Digital Intermediate Assistant |
| Production | Abby Lorts | Location Production Assistant |
| Crew | Ina Haybaeck-Rogers | Choreographer |
| Production | Frank Cuomo | Post Production Coordinator |
| Production | Olivier Agostini | Production Assistant |
| Production | Cliff Zimowski | Additional Production Assistant |
| Sound | Jay Duerr | Music Editor |
| Crew | Michael Franck | Aerial Coordinator |
| Visual Effects | Eric Pender | CG Artist |
| Crew | Michelle Johnston | Choreographer |
| Crew | Teresa Lang | Thanks |
| Crew | Michelle Sleger | Stand In |
| Crew | Linda Cohn | Thanks |
